Positive and Negative Selection on Mammalian Y Chromosomes
نویسندگان
چکیده
منابع مشابه
Positive and negative selection on mammalian Y chromosomes.
Y chromosomes are genetically degenerate in most organisms studied. The loss of genes from Y chromosomes is thought to be due to the inefficiency of purifying selection in nonrecombining regions, which leads to the accumulation of deleterious mutations via the processes of hitchhiking, background selection, and Muller's ratchet. As the severity of these processes depends on the number of functi...
متن کاملNatural selection on human Y chromosomes.
The paternally inherited Y chromosome has been widely used in population genetic studies to understand relationships among human populations. Our interpretation of Y chromosomal evidence about population history and genetics has rested on the assumption that all the Y chromosomal markers in the male-specific region (MSY) are selectively neutral. However, the very low diversity of Y chromosome h...
متن کاملSequencing and Annotating New Mammalian Y Chromosomes
Steve Rozen, Wesley C. Warren, George Weinstock, Stephen J. O’Brien, Richard A. Gibbs, Richard K. Wilson, David C. Page 1 Howard Hughes Medical Institute, Whitehead Institute, and Department of Biology, Massachusetts Institute of Technology, Cambridge, Massachusetts 02142 2 Genome Sequencing Center, Washington University School of Medicine, St Louis, Missouri 63108 3 Human Genome Sequencing Cen...
متن کاملNatural Selection Reduced Diversity on Human Y Chromosomes
The human Y chromosome exhibits surprisingly low levels of genetic diversity. This could result from neutral processes if the effective population size of males is reduced relative to females due to a higher variance in the number of offspring from males than from females. Alternatively, selection acting on new mutations, and affecting linked neutral sites, could reduce variability on the Y chr...
متن کاملThe Biology and Evolution of Mammalian Y Chromosomes.
Mammals have the oldest sex chromosome system known: the mammalian X and Y chromosomes evolved from ordinary autosomes beginning at least 180 million years ago. Despite their shared ancestry, mammalian Y chromosomes display enormous variation among species in size, gene content, and structural complexity. Several unique features of the Y chromosome--its lack of a homologous partner for crossing...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Molecular Biology and Evolution
سال: 2005
ISSN: 1537-1719,0737-4038
DOI: 10.1093/molbev/msi128